The town is named after the late Vice Governor Salvador Benedicto who played an important role in the setting up of a Revolutionary Government in Negros Island particularly in Brgy. Igmaya-an, when the country was occupied by the Japanese during World War II.

The territorial formation of Don Salvador Benedicto is composed of two barangays from the Municipality of Murcia (Pandanon and Igmayaan), three barangays from the City of San Carlos (Kumaliskis, Bunga, and Pinowayan-Prosperidad) and two barangays from the Municipality of Calatrava (Bagong Silang-Marcelo and Bago-Lalong). 

Sixty percent of the residents speak Cebuano and the rest speak Ilonggo and other dialects. The people have adopted the art of kali otherwise known as arnis or escrima as their cultural heritage. The traditional martial arts of the Filipino people since the 7th century, it is designed for physical training, mental development and spiritual upliftment as well as strengthening of moral value foundation. The craft is highlighted every year during the celebration of the Kali-Kalihan Harvest Festival that also showcases various cultural and traditional activities of the people.